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A personalized vitamin D regimen for people who have already had a heart attack was linked to a markedly lower chance of another one, according to a study presented on Sunday at the American Heart Association’s Scientific Sessions 2025.
Researchers reported that patients receiving tailored supplements had a 52% lower risk of a subsequent heart attack than those on standard care.
Adults with established heart disease were randomly assigned to standard care or to individualized vitamin D supplementation.
In the treatment group, doses were adjusted every three months until blood levels surpassed 40 nanograms per milliliter (ng/mL), a unit that indicates the concentration of a substance in blood.
Over nearly four years of follow-up, tailored supplementation was associated with fewer repeat heart attacks.
The study did not find a significant reduction in the primary composite outcome—death, hospitalization for heart failure, or stroke—yet the decline in recurrent heart attacks stood out as a potential benefit.
“We encourage people with heart disease to discuss vitamin D blood testing and targeted dosing with their health care professionals to meet their individual needs,” said the study’s principal investigator, Dr. Heidi May.
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